本公司经销ADAR1 （N-terminus），双链RNA腺苷酸脱氨基酶抗体（N端），克隆类型为polyclonal，宿主来源是Rabbit，ADAR1 （N-terminus）双链RNA腺苷酸脱氨基酶抗体（N端）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2167R
英文名称：Anti-ADAR1 （N-terminus）
中文名称：双链RNA腺苷酸脱氨基酶抗体（N端）
其他名称：136kDa double stranded RNA binding protein; Adar 1; ADAR; Adar1; Adenosine deaminase RNA specific 1; Adenosine deaminase RNA specific; Adenosine deaminase that act on RNA; AV242451; Double stranded RNA specific adenosine deaminase; Double-stranded RNA-specific editase Adar; Drada; Dsh; Dsrad; dsRNA adenosine deaminase; EC 3.5.4.-; G1P1; IFI 4; IFI4; Ifi4 protein; Interferon induced protein 4; Interferon inducible protein 4; K88dsrbp; mZaADAR; p136; Pre-mRNA adenosine deaminase; RNA adenosine deaminase 1; RNA-editing deaminase 1; RNA-editing enzyme 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 135kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：ADAR1 converts adenosine to inosine in dsRNA, which destabilizes the dsRNA helix. This activity is important for various functions like site-specific RNA editing of transcripts of the glutamate receptors ａnd modifying viral RNA genomes （which may be responsible for hypermutation of certain negative-stranded viruses, e.g., measles virus）. ADAR1 also binds to short interfering RNAs （siRNA） without editing them ａnd suppresses siRNA-mediated RNA interference. This protein is ubiquitously expressed, with the highest levels being found in brain ａnd lung.Function : Converts multiple adenosines to inosines ａnd creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes ａnd may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor （GLUR） subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site ａnd HOTSPOT1. Binds to short interfering RNAs （siRNA） without editing them ａnd suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 ａnd up-regulates ILF3-mediated gene expression.Subunit : Homodimer. Isoform 1 interacts with ILF2/NF45 ａnd ILF3/NF90.Subcellular Location : Cytoplasm. Nucleus, nucleolus. Isoform 1: Cytoplasm. Note=Found predominantly in cytoplasm but appears to shuttle between the cytoplasm ａnd nucleus. Isoform 5: Nucleus, nucleolus.Tissue Specificity : Ubiquitously expressed, highest levels were found in brain ａnd lung.Post-translational modifications : Sumoylation reduces RNA-editing activity.DISEASE : Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria （DSH） [MIM:127400]; also known as reticulate acropigmentation of Dohi. DSH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented ａnd hypopigmented macules distributed on the dorsal parts of the hands ａnd feet.Similarity : Contains 1 A to I editase domain.Contains 2 DRADA repeats. Contains 3 DRBM （double-stranded RNA-binding） domains.ADAR腺苷脱氨酶是一种存在于嘌呤新陈代谢的酶，属于巯基酶。