本公司经销phospho-AKT3 （Ser472），磷酸化蛋白激酶AKT3抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-AKT3 （Ser472）磷酸化蛋白激酶AKT3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5209R
英文名称：Anti-phospho-AKT3 （Ser472）
中文名称：磷酸化蛋白激酶AKT3抗体
其他名称：AKT3 kinase; DKFZP434N0250; PKB Gamma; PKBG; PRKBG; Protein Kinase AKT3; Protein Kinase B Gamma ; RAC gamma; RAC Gamma Serine/Threonine Protein Kinase; RACPK Gamma; Serine threonine protein kinase Akt 3; Serine Threonine Protein Kinase AKT3; STK 2; STK2; V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma; VAKT Murine Thymoma Viral Oncogene Homolog 3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, chk, cow, pig, shp, Rb
产品介绍：Akt, protein kinase B （PKB）, is a serine/threonine kinase which is involved in many cellular signaling pathways ａnd acts as a transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase （PI 3 kinase）. The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3 kinase ａnd Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells （1/alpha, 2/beta ａnd 3/gamma）. IGF1 leads to the activation of AKT3, which may play a role in regulating cell survival. It is capable of phosphorylating several known proteins.Subunit : Interacts （via PH domain） with TCL1A; this enhances AKT3 phosphorylation ａnd activation. Interacts with TRAF6.Subcellular Location : Cytoplasm. Nucleus. Cell membrane （By similarity）. Note=Nucleus after activation by integrin-linked protein kinase 1 （ILK1） （By similarity）. Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 ａnd Ser-473 leading to its activation ａnd the activated form translocates to the nucleus.Tissue Specificity : In adult tissues, it is highly expressed in brain, lung ａnd kidney, but weakly in heart, testis ａnd liver. In fetal tissues, it is highly expressed in heart, liver ａnd brain ａnd not at all in kidney.Similarity : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 PH domain.Contains 1 protein kinase domain.