本公司经销phospho-AKT2 （Ser474），磷酸化蛋白激酶B2抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-AKT2 （Ser474）磷酸化蛋白激酶B2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4089R
英文名称：Anti-phospho-AKT2 （Ser474）
中文名称：磷酸化蛋白激酶B2抗体
其他名称：Akt2（Phospho-Ser474）; C AKT; MGC9965; Oncogene AKT1; PKB; PRKBA; Protein Kinase B Alpha; RAC Alpha; RAC; RAC PK Alpha; RAC Serine/Threonine Protein Kinase; vAKT Murine Thymoma Viral Oncogene Homolog 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, shp, pig, dog, chk, cow, Rb
产品介绍：IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. [subcellular location] Cytoplasmic ａnd membrane-associated after cell stimulation leading to its translocation. In adult tissues, it is highly expressed in brain, lung ａnd kidney, but weakly in heart, testis ａnd liver. In fetal tissues, it is highly expressed in heart, liver ａnd brain ａnd not at all in kidney. Belongs to the Ser/Thr protein kinase family. RAC subfamily.Subunit : Interacts （via PH domain） with TCL1A; this enhances AKT3 phosphorylation ａnd activation. Interacts with TRAF6.Subcellular Location : Cytoplasm. Nucleus. Cell membrane （By similarity）. Note=Nucleus after activation by integrin-linked protein kinase 1 （ILK1） （By similarity）. Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 ａnd Ser-473 leading to its activation ａnd the activated form translocates to the nucleus.Tissue Specificity : Widely expressed. Low levels found in liver with slightly higher levels present in thymus ａnd testis.Similarity : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 PH domain.Contains 1 protein kinase domain.