本公司经销phospho-APP/ABPP （Thr743），磷酸化APP淀粉样肽前体蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-APP/ABPP （Thr743）磷酸化APP淀粉样肽前体蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5167R
英文名称：Anti-phospho-APP/ABPP （Thr743）
中文名称：磷酸化APP淀粉样肽前体蛋白抗体
其他名称：A4 amyloid protein; A4; AAA; ABETA; ABPP; AD 1; AD1; Alzheimer disease 1; Alzheimer disease; Alzheimer＇s disease amyloid protein; Amyloid beta （A4） precursor protein; Amyloid beta A4 protein; Amyloid beta A4 protein precursor isoform b; Amyloid beta A4 protein precursor isoform c; Amyloid beta A4 protein precursor isoform a; Amyloid beta A4 protein precursor isoform b; Amyloid beta A4 protein precursor isoform c; Amyloid beta protein; Amyloid beta-peptide; Amyloid of aging ａnd alzheimer disease; APP; APP I ; APPI; Beta amyloid peptide; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Human mRNA for amyloid A4 precursor of Alzheimer＇s disease; PN 2; PN II; PN2; PreA4; Protease nexin II.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 76kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, cow, dog, pig, chk
产品介绍：Amyloid Precursor Protein （APP） functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase ａnd presenilin 1. APP is important for neurite growth, neuronal adhesion ａnd axonogenesis. Immature APP （N-glycosylated in the endoplasmic reticulum） moves to the Golgi complex where complete maturation occurs （O-glycosylated ａnd sulfated）. After alpha-secretase cleavage, soluble APP is released into the extracellular space ａnd the C-terminal is internalized to endosomes ａnd lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment ａnd returns to the cell surface. APP is expressed in the brain, kidney, heart ａnd spleen of fetal tissues; it is induced during neuronal differentiation. In adult brain, highest expression of APP is found in the frontal lobe of the cortex ａnd in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri ａnd the temporal associated cortex. Defects in APP are a cause of autosomal dominant Alzheimer＇s disease （AD）. Phosphorylation of APP at Tyr757 ａnd 762 is important for MAPK8IP1, APBA1, shcA/shcC ａnd DAB1 binding. Binding interactions regulated by phosphorylation determine the localisation ａnd the function of APP. Therefore Amyloid Precursor Protein （phospho Y757） antibody will be a useful tool in tracing the processing, distribution ａnd interaction of APP.