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Anti-APE/Girdin肌动蛋白结合蛋白Girdin抗体
点击次数：290发布时间：2012/12/26 5:26:05
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5150R
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货号：BY-5150R
英文名称：Anti-APE/Girdin
中文名称：肌动蛋白结合蛋白Girdin抗体
其他名称：Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 206kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, Rb, hrs
产品介绍：Girdin enhances phosphoinositide 3 kinase （PI3K） dependent phosphorylation ａnd kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 ａnd FOXO1A/FKHR, ａnd regulates DNA replication ａnd cell proliferation. It is essential for the integrity of the actin cytoskeleton ａnd for cell migration. Required for formation of actin stress fibers ａnd lamellipodia.Subunit : Homodimer.Subcellular Location : Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium.Tissue Specificity : Expressed ubiquitously.Similarity : Belongs to the CCDC88 family.Girdin蛋白是一种新发现的肌动蛋白结合蛋白,能与Akt相互作用,在促进细胞的迁移及血管生成等方面具有重要作用,也是肿瘤发生、发展、肿瘤细胞运动等病理过程中的重要步骤和关键环节.
