本公司经销Apolipoprotein E/Apo E2，载脂蛋白E抗体，克隆类型为polyclonal，宿主来源是Rabbit，Apolipoprotein E/Apo E2载脂蛋白E抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4892R
英文名称：Anti-Apolipoprotein E/Apo E2
中文名称：载脂蛋白E抗体
其他名称：APOE; Apolipoprotein E precursor; AD2; Alzheimer disease 2; Apo E; ApoE; APOEA; ApolipoproteinE; Apoprotein; MGC1571; Apo E2; ApoE2; APOE 2; Apolipoprotein E; Apolipoprotein E2; LDLCQ5; LPG;AD2;Alzheimer disease 2;Apo E;Apo-E;ApoE;APOE_HUMAN;APOEA;Apolipoprotein E;Apolipoprotein E3;ApolipoproteinE;Apoprotein;MGC1571.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells ａnd peripheral cells ａnd is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, ａnd E4, which differ from one another by a single amino-acid substitution. Compared with E3 ａnd E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol ａnd triglycerides levels which are the consequence of impaired clearance of chylomicron ａnd VLDL remnants.Function : Mediates the binding, internalization, ａnd catabolism of lipoprotein particles. It can serve as a ligand for the LDL （apo B/E） receptor ａnd for the specific apo-E receptor （chylomicron remnant） of hepatic tissues.Subcellular Location : Secreted.Tissue Specificity : Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins （VLDL） ａnd 1-2% of high density lipoproteins （HDL）. APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney ａnd muscle.DISEASE : Defects in APOE are a cause of hyperlipoproteinemia type 3 （HLPP3） [MIM:107741]; also known as familial dysbetalipoproteinemia. Individuals with HLPP3 are clinically characterized by xanthomas, yellowish lipid deposits in the palmar crease, or less specific on tendons ａnd on elbows. The disorder rarely manifests before the third decade in men. In women, it is usually expressed only after the menopause. The vast majority of the patients are homozygous for APOE*2 alleles. More severe cases of HLPP3 have also been observed in individuals heterozygous for rare APOE variants. The influence of APOE on lipid levels is often suggested to have major implications for the risk of coronary artery disease （CAD）. Individuals carrying the common APOE*4 variant are at higher risk of CAD.Genetic variations in APOE are associated with Alzheimer disease type 2 （AD2） [MIM:104310]. It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, ａnd deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques ａnd vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide （s）, derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments （CTFs） ａnd the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Note=The APOE*4 allele is genetically associated with the common late onset familial ａnd sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% ａnd mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known.Defects in APOE are a cause of sea-blue histiocyte disease （SBHD） [MIM:269600]; also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease ａnd other sphingolipidoses.Defects in APOE are a cause of lipoprotein glomerulopathy （LPG） [MIM:611771]. LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, ａnd distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese ａnd Chinese origin. The disorder has rarely been described in Caucasians.Similarity : Belongs to the apolipoprotein A1/A4/E family.ApoE 是在肝脏中合成的极低密度脂蛋白的组分，也是在细胞间转运胆固醇的高密度脂蛋白的一种亚类.