本公司经销Ankyrin erythroid，红细胞蛋白Ank1抗体，克隆类型为polyclonal，宿主来源是Rabbit，Ankyrin erythroid红细胞蛋白Ank1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7594R
英文名称：Anti-Ankyrin erythroid
中文名称：红细胞蛋白Ank1抗体
其他名称：ANK; ANK-1; Ank1; ANK1_HUMAN; Ankyrin 1; Ankyrin 1, erythrocytic; Ankyrin R; Ankyrin-1; Ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, pig, dog
产品介绍：Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton ａnd play key roles in activities such as cell motility, activation, proliferation, contact ａnd the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; ａnd a carboxy-terminal regulatory domain which is the least conserved ａnd subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain ａnd muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008].Subcellular Location : Isoform Er1: Cytoplasm, cytoskeleton. Isoform Mu17: Membrane. Cytoplasm, myofibril, sarcomere, M line. Isoform Mu18: Sarcoplasmic reticulum. Isoform Mu19: Sarcoplasmic reticulum. Isoform Mu20: Sarcoplasmic reticulum.Tissue Specificity : Isoform Mu17, isoform Mu18, isoform Mu19 ａnd isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.Similarity : Contains 23 ANK repeats.Contains 1 death domain.Contains 1 ZU5 domain.