产品展示
Anti-AANAT芳香胺N-乙酰化转移酶抗体
点击次数：235发布时间：2012/12/26 5:44:33
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-3914R
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详细内容
货号：BY-3914R
英文名称：Anti-AANAT
中文名称：芳香胺N-乙酰化转移酶抗体
其他名称：AANAT; Arylalkylamine N acetyltransferase; Serotonin N-acetyltransferase; SNAT.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog
产品介绍：The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis ａnd controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity ａnd sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins ａnd thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].Subunit : Monomer.Subcellular Location : Cytoplasm.Tissue Specificity : Highly expressed in pineal gland ａnd at lower levels in the retina. Weak expression in several brain regions ａnd in the pituitary gland.Similarity : Belongs to the acetyltransferase family. AANAT subfamily.Contains 1 N-acetyltransferase domain.AANAT-褪黑素合成限速酶.
