本公司经销Arginase II，精氨酸酶2抗体，克隆类型为polyclonal，宿主来源是Rabbit，Arginase II精氨酸酶2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11397R
英文名称：Anti-Arginase II
中文名称：精氨酸酶2抗体
其他名称：ARG 2; ARG2; ARGI2_HUMAN; Arginase2; Arginase liver; Arginase type II; Arginase II; ArginaseII; Arginase-II; Arginase1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, chk, Rb
产品介绍：Arginase I （also designated liver-type arginase）, which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine ａnd urea （1）. The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein ａnd contains a binuclear manganese cluster （2-4）. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity ａnd subcellular location （5,6）. Specifically, arginase II localizes to the mitochondria （5,6）. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver （5,6）. The human arginase II gene, which maps to chromosome 14q24.1, encodes a 354 amino acid protein （3,5-7）. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence （5,6）.Function : May play a role in the regulation of extra-urea cycle arginine metabolism ａnd also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum ａnd the vagina, arginase II plays a role in both male ａnd female sexual arousal. It is therefore a potential target for the treatment of male ａnd female sexual arousal disorders.Subunit : Homotrimer.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed most strongly in kidney ａnd prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis ａnd gut, but apparently not in the liver, heart ａnd pancreas.Similarity : Belongs to the arginase family.