本公司经销AKR1C3/DD3，醛固酮还原酶家族1成员C3抗体，克隆类型为polyclonal，宿主来源是Rabbit，AKR1C3/DD3醛固酮还原酶家族1成员C3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11401R
英文名称：Anti-AKR1C3/DD3
中文名称：醛固酮还原酶家族1成员C3抗体
其他名称：17 beta HSD 5; 17 beta hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 2-dihydrobenzene-1; 2-diol dehydrogenase; 3 alpha hydroxysteroid dehydrogenase type II; 3-alpha-HSD type 2; 3-alpha-HSD type II; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; AK1C3_HUMAN; AKR1 C3; AKR1C3; Aldo keto reductase family 1 member C3; Aldo-keto reductase family 1 member C3; brain; Chlordecone reductase; Chlordecone reductase homolog HAKRb; DD-3; DD3; DDH1; DDX; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase X; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; Indanol dehydrogenase; KIAA0119; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; Trans-1; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Type IIb 3 alpha hydroxysteroid dehydrogenase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, dog, pig, cow, hrs, Rb
产品介绍：DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol ａnd trans-naphthalenedihydrodiol.Human liver contains isoforms of dihydrodiol dehydrogenase （DD1, DD2, DD3 ａnd DD4）, which belong to the aldo-oxo reductase/aldo-keto reductase （AKR） superfamily, have 20Alpha- or 3Alpha-hydroxysteroid dehydrogenase （HSD） activity. DD1 is also designated AKR1C1, DDH or DDH1 while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 ａnd 3Alpha-HSD are alternate designations for DD3, while DD4 also can be called AKR1C4, CD or CHDR. DD1 ａnd DD2 are 20Alpha-HSDs, whereas DD3 ａnd DD4 are the 3Alpha-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides ａnd steroid hormones, ａnd are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20Alpha-HSD catalyzes the reaction of progesterone to the inactive form 20Alpha-hydroxyprogesterone. The 3Alpha-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 ａnd DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver.Function : Catalyzes the conversion of aldehydes ａnd ketones to alcohols. Catalyzes the reduction of prostaglandin （PG） D2, PGH2 ａnd phenanthrenequi （PQ） ａnd the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- ａnd 20-alpha HSD. Can interconvert active androgens, estrogens ａnd progestins with their cognate inactive metabolites. Preferentially transforms androstenedione （4-dione） to testosterone.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate ａnd testis. The dominant HSD in prostate ａnd mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei ａnd amygdala. Weaker expression in the hippocampus, substantia nigra ａnd caudate.Similarity : Belongs to the aldo/keto reductase family.