产品展示
Anti-BRD8甲状腺激素受体共激活蛋白抗体
点击次数：202发布时间：2012/12/26 5:54:43
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-6290R
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详细内容
货号：BY-6290R
英文名称：Anti-BRD8
中文名称：甲状腺激素受体共激活蛋白抗体
其他名称：BRD8; Bromodomain containing 8; p120; Skeletal muscle abundant protein 2; Skeletal Muscle Abundant Protein; SMAP; SMAP2; Thyroid hormone receptor coactivating protein 120kDa; Thyroid Hormone Receptor Coactivating Protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 120kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：BRD8 may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors （NR）. Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 ａnd THRB/ERBA2. At least isoform 1 ａnd isoform 2 are components of the NuA4 histone acetyltransferase （HAT） complex which is involved in transcriptional activation of ｓelect genes principally by acetylation of nucleosomal histone H4 ａnd H2A. This modification may both alter nucleosome - DNA interactions ａnd promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene ａnd proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest ａnd replicative senescence, apoptosis, ａnd DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. It interacts with MYC ａnd adenovirus E1A protein.
