本公司经销Bcl-2，Bcl-2抗体，克隆类型为polyclonal，宿主来源是Rabbit，Bcl-2Bcl-2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-4563R
英文名称：Anti-Bcl-2
中文名称：Bcl-2抗体
其他名称：Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 26kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb, hrs, cow, dog
产品介绍：The Bcl-2 gene was isolated at the chromosomal breakpoint of t（14;18）-bearing follicular B cell lymphomas（1,2）.Bcl-2 blocks cell death following a variety of stimuli ａnd confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal （3,5）.Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action （6,7）.A more recently identified protein,designated Bax p21（i.e., Bcl-associated X protein ）,has extensive amino acid homology with Bcl-2 ａnd both homodimerizes ａnd forms heterodimers with Bcl-2（8）. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line ａnd Bax also counters the death repressor activty of Bcl-2（8）.Subunit : Forms homodimers, ａnd heterodimers with BAX, BAD, BAK ａnd Bcl-X（L）. Heterodimerization with BAX requires intact BH1 ａnd BH2 motifs, ａnd is necessary for anti-apoptotic activity. Interacts with EI24 （By similarity）. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 ａnd TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria ａnd probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner. Interacts with RAF1 （the ＇Ser-338＇ ａnd ＇Ser-339＇ phosphorylated form）. Interacts （via the BH4 domain） with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex ａnd inhibits the anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex.Subcellular Location : Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.Tissue Specificity : Expressed in a variety of tissues.Similarity : Belongs to the Bcl-2 family.Bcl-2基因是指B-cell lymphoma gene。人体滤泡B细胞淋巴瘤中过量表达的原癌基因。由于染色体t（14；18）易位，将Bcl-2基因置于免疫球蛋白重链的转录调控下，使其表达失控。在细胞系中其过量表达能延长细胞存活期而不诱导细胞增殖。它是哺乳动物中细胞调亡的抑制基因。参与细胞凋亡的调控。肿瘤中的Bcl-2基因可提高侵润性瘤细胞的生存能力。主要用于滤胞型淋巴瘤、毛细管性白血病及细胞凋亡等方面的研究。目前研究认为：Bcl-2也是细胞凋亡的一种抑制因子、参与细胞凋亡调控，可以用于各种恶性肿瘤的细胞凋亡的研究。