产品展示
Anti-BARD1乳腺癌易感基因环状结构域蛋白抗体
点击次数：271发布时间：2012/12/26 5:58:16
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-4291R
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货号：BY-4291R
英文名称：Anti-BARD1
中文名称：乳腺癌易感基因环状结构域蛋白抗体
其他名称：BARD-1; Bard1; Bard 1; BARD1_HUMAN; BRCA1 associated RING domain 1; BRCA1 associated RING domain gene 1; BRCA1 associated RING domain protein 1; BRCA1-associated RING domain protein 1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 85kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, pig, dog, chk
产品介绍：BRCA1 Associated RING Domain gene 1 （BARD1） interacts with the N terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo ａnd in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N terminal RING motif ａnd the C terminal BRCT domain. The RING motif is a cysteine rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes ａnd dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. BARD1 also plays a role in mediating apoptotic stress ａnd p53 dependent.Subunit : Homo- ａnd heterodimer. HeterodimerSubcellular Location : Nucleus.Similarity : Contains 4 ANK repeats. Contains 2 BRCT domains. Contains 1 RING-type zinc finger.
