本公司经销BDNF，脑源神经营养因子抗体，克隆类型为polyclonal，宿主来源是Rabbit，BDNF脑源神经营养因子抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0248R
英文名称：Anti-BDNF
中文名称：脑源神经营养因子抗体
其他名称：Abrineurin; Brain Derived Neurotrophic Factor; MGC34632; Neurotrophin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 28kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, hrs, Rb, Gpig, dog
产品介绍：Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor （NGF）, originally discovered in the 1950s as a soluble peptide promoting the survival of, ａnd neurite outgrowth from, sympathetic ganglia. More recently, three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor （BDNF）, neurotrophin-3 （NT-3） ａnd neurotrophin-4 （NT-4）, also designated NT-5. These various neurotrophins stimulate the in vitro survival of distinct but partially overlapping populations of neurons. The Trk A receptor is the preferential receptor for NGF, but also binds NT-3 ａnd NT-4. The Trk B receptor binds equally well to both BDNF ａnd NT-4 ａnd to a lesser extent NT-3, while the Trk C receptor only binds NT-3. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Belongs to the NGF-beta family. Function : During development, promotes the survival ａnd differentiation of selected neuronal populations of the peripheral ａnd central nervous systems. Participates in axonal growth, pathfinding ａnd in the modulation of dendritic growth ａnd morphology. Major regulator of synaptic transmission ａnd plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation （LTP）, long-term depression （LTD）, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.Subunit : Monomers ａnd homodimers. Binds to NTRK2/TRKB.Subcellular Location : Secreted.Tissue Specificity : Brain. Highly expressed in hippocampus, amygdala, cerebral cortex ａnd cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate ａnd placenta.Post-translational modifications : The propeptide is N-glycosylated ａnd glycosulfated.Converted into mature BDNF by plasmin （PLG）.DISEASE : Defects in BDNF are a cause of congenital central hypoventilation syndrome （CCHS） [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory ａnd arousal responses to hypercapnia ａnd hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.神经生物学相关蛋白（Neurobiology） 人脑源性神经营养因子（BDNF）和神经营养素-3（NT-3）神经生长因子（NGF）属于神经营养因子（NTF）家族的组成成员，具有促进早期神经元的增殖与分化，维持成熟神经元的存活的生物学功能,能调控神经元再生的微环境、可促进运动神经元的存活和生长并能防止它受损及死亡。对治疗神经系统疾病有广泛的临床应用前景。 目前已经用于某些疾病的临床试验：如早期老年性痴呆症、帕金森氏症、糖尿病、艾滋病或其他原因引起的外周神经损伤等研究。 产品图片Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-BDNF Polyclonal Antibody, Unconjugated（bs-0248R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingProtein: 1.rat brain lysates, 30ug;2.rat heart lysates, 30ugPrimary: Anti-BDNF （bs-0248R） at 1:200Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bse-0295G） at 1: 3000Predicted band size : 13kD,25kDObserved band size : 25kDBDNF_HUMAN:Sigal（1-18）, Propeptide（19-128）, Mature chain（129-247）