本公司经销Bim/BCL2L11，细胞死亡调解子抗体，克隆类型为polyclonal，宿主来源是Rabbit，Bim/BCL2L11细胞死亡调解子抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1488R
英文名称：Anti-Bim/BCL2L11
中文名称：细胞死亡调解子抗体
其他名称：Bcl-2 interacting mediator of cell death; Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death; BCL2L11; BAM; BIM; BIM-alpha6; BIM-beta6; BIM-beta7; BimEL; BimL; BOD.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 22kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, shp, pig, dog
产品介绍：Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers ａnd act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 （BH3）. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X（L）, ａnd MCL1, ａnd to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor （NGF）, as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal ａnd lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq].Function : Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 ａnd isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL ａnd BimS. Isoform Bim-gamma induces apoptosis.Subunit : Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X（L）, BCL2A1/BFL-1, ａnd BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK.Subcellular Location : Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion.Tissue Specificity : Isoform BimEL, isoform BimL ａnd isoform BimS are the predominant isoforms ａnd are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine ａnd colon, ａnd in lower levels in spleen, prostate, testis, heart, liver ａnd kidney.Similarity : Belongs to the Bcl-2 family.Bim是Bcl-2家族BH3-only亚家族的成员,是一种重要的凋亡调节蛋白，具有助凋亡活性作用。Bim广泛表达于正常细胞,对防御自身免疫、维持造血细胞稳态有重要意义,并具有肿瘤抑制因子活性.Bim的生理作用与它调节细胞凋亡的功能有关。