产品展示
Anti-BidBH3结构域凋亡诱导蛋白抗体
点击次数：311发布时间：2012/12/26 6:06:08
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1153R
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货号：BY-1153R
英文名称：Anti-Bid
中文名称：BH3结构域凋亡诱导蛋白抗体
其他名称：BH3 interacting domain death agonist; p22 BID; BID;） BH3-interacting domain death agonist; AltName: BH3-interacting domain death agonist p15; Bid Cleavage Site: BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria ａnd releases its potent proapoptotic activity, which in turn induces cytochrome c release ａnd mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
