本公司经销BKCa channels/KCNMA，钙激活钾通道蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，BKCa channels/KCNMA钙激活钾通道蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0868R
英文名称：Anti-BKCa channels/KCNMA
中文名称：钙激活钾通道蛋白抗体
其他名称：Maxi Potassium channel alpha; bA205K10.1; BK channel; BKCA alpha; BKCA alpha subunit; BKTM; Calcium activated potassium channel subfamily M subunit alpha 1; Calcium activated potassium channel subunit alpha 1; DKFZp686K1437; Drosophila slowpoke like; hSlo; K（VCA）alpha; KCa1.1; KCNMA 1; KCNMA; KCNMA1; Large conductance calcium activated potassium channel subfamily M alpha member 1; Maxi K; Maxi K channel; MaxiK; Potassium large conductance calcium activated channel subfamily M alpha member 1; SAKCA; Slo 1; SLO alpha; SLO; Slo homolog; Slo1; Slowpoke homolog; Stretch activated Kca channel.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 138kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs, shp, Rb, dog
产品介绍：MaxiK channels are large conductance, voltage ａnd calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone ａnd neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, ａnd the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha ａnd beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].Function : Potassium channel activated by both membrane depolarization or increase in cytosolic Ca（2+） that mediates export of K（+）. It is also activated by the concentration of cytosolic Mg（2+）. Its activation dampens the excitatory events that elevate the cytosolic Ca（2+） concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, ａnd innate immunity. In smooth muscles, its activation by high level of Ca（2+）, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number ａnd kinetic properties partly determine the characteristic frequency of each hair cell ａnd thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status ａnd its combination with modulating beta subunits. Highly sensitive to both iberiotoxin （IbTx） ａnd charybdotoxin （CTX）.Subunit : Homotetramer.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Widely expressed. Except in myocytes, it is almost ubiquitously expressed.Post-translational modifications : Phosphorylated （Probable）. Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.DISEASE : Defects in KCNMA1 are the cause of generalized epilepsy ａnd paroxysmal dyskinesia （GEPD） [MIM:609446]. Epilepsy is one of the most common ａnd debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy ａnd paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood ａnd patients may have seizures only, dyskinesia only, or both.Similarity : Belongs to the potassium channel family. Calcium-activated （TC 1.A.1.3） subfamily. KCa1.1/KCNMA1 sub-subfamily.Contains 1 RCK N-terminal domain.通道蛋白（Channel Protein）