本公司经销B-Raf，B Raf抗体，克隆类型为polyclonal，宿主来源是Rabbit，B-RafB Raf抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1089R
英文名称：Anti-B-Raf
中文名称：B Raf抗体
其他名称：94 kDa B raf protein; B raf 1; B Raf proto oncogene serine threonine protein kinase; BRAF 1; Braf; BRAF1; cRmil; MGC126806; MGC138284; Murine sarcoma viral （v-raf） oncogene homolog B1; Murine sarcoma viral v raf oncogene homolog B1; p94; RAFB 1; RAFB1; v raf murine sarcoma viral oncogene homolog B1; FLJ95109; B Raf.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 84（hu）/89（mo, rat）kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, at, cow, Rb, hrs, chk, dog
产品介绍：The Raf kinases are important intermediates in signal transduction. Raf protein family members, including A Raf ａnd B Raf, have intrinsic serine/threonine kinase activity. Interaction between Ras proteins ａnd Raf proteins results in Raf-mediated phosphorylation ａnd activation of MEK （also known as MAP kinase kinase）. Defects in BRAF are involved in a wide range of cancers. B-Raf is a serine/threonine protein kinase that acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. 1 BRAF is important for the regulation of cell proliferation ａnd determination of cell fate during embryogenesis. BRAF acts downstream of Ras ａnd upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, ａnd differentiation in response to growth factors, cytokines, ａnd hormones.Subunit : Monomer. Homodimer. Heterodimerizes with RAF1, ａnd the heterodimer possesses a highly increased kinase activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated ａnd enhanced by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the heterodimer by phosphorylating BRAF at Thr-753. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 ａnd RGS14. Interacts with RIT1. Interacts （via N-terminus） with RGS14 （via RBD domains）; the interaction mediates the formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1. Interacts with DGKH.Subcellular Location : Nucleus. Cytoplasm. Cell membrane. Tissue Specificity : Brain ａnd testis.Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain.Contains 1 RBD （Ras-binding） domain.BRAF蛋白是有丝分裂原活化的蛋白激酶/细胞外信号调节激酶途径蛋白。正常的B-Raf蛋白的功能是传递来自细胞膜的信号,在Ras-Raf-MEK-ERK信号转导调节途径中有着重要的作用. BRAF是在癌细胞的生长和存活中起到关键作用的蛋白质,并且在大多数恶性黑素瘤患者和少数结肠癌、乳腺癌和肺癌患者中发生突变，目前BRAF也用于恶性黑素瘤和肿瘤的研究。