本公司经销BRCA1/BAP1，乳腺癌易感基因1抗体，克隆类型为polyclonal，宿主来源是Rabbit，BRCA1/BAP1乳腺癌易感基因1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0802R
英文名称：Anti-BRCA1/BAP1
中文名称：乳腺癌易感基因1抗体
其他名称：BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53 ,Breast cancer susceptbility gene 1
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 81kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability ａnd acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant （BRCA1a＇） uses different splice site in the 5＇ UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein （isoform 1） which is also known as p220. Variants BRCA1a ａnd BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.Function : E3 ubiquitin-protein ligase that specifically mediates the formation of ＇Lys-6＇-linked polyubiquitin chains ａnd plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation. Contributes to homologous recombination repair （HRR） via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.Subunit : Contains 2 BRCT domains.Contains 1 RING-type zinc finger.Subcellular Location : Cytoplasm; Nucleus. Localizes at sites of DNA damage at double-strand breaks （DSBs） ａnd recruitment to DNA damage sites is mediated by the BRCA1-A complex.Tissue Specificity : Isoform 1 ａnd isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast ａnd ovarian cancer cell lines.DISEASE : Defects in BRCA1 are a cause of susceptibility to breast cancer （BC） [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically ａnd genetically heterogeneous. Important genetic factors have been indicated by familial occurrence ａnd bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Note=Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer. Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3-fold increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination.BRCA1基因是*早被发现的乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关产品图片Tissue/cell: Human nasopharyngeal carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-BRCA1/BAP1 Polyclonal Antibody, Unconjugated（bs-0802R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining