本公司经销BRCA2，乳腺癌易感基因2抗体，克隆类型为polyclonal，宿主来源是Rabbit，BRCA2乳腺癌易感基因2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1210R
英文名称：Anti-BRCA2
中文名称：乳腺癌易感基因2抗体
其他名称：BRCA 2; BRCA1/BRCA2 containing complex subunit 2; BRCC 2; BRCC2; Breast ａnd ovarian cancer susceptibility gene early onset; Breast cancer 2 early onset; Breast Cancer 2 tumor suppressor; Breast cancer susceptibility protein BRCA2; Breast cancer type 2 susceptibility protein; FACD; FAD 1; FAD; FAD1; FANCB; FANCD 1; FANCD; FANCD1; Fanconi anemia complementation group D1; Fanconi anemia group D1 protein; OTTHUMP00000018803; OTTHUMP00000042401.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 384kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow, Rb, dog, chk
产品介绍：Inherited mutations in BRCA1 ａnd this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 ａnd BRCA2 are involved in maintainance of genome stability, specificallythe homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, ａnd these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity （LOH） of the wild-type allele.Function : Involved in double-strand break repair and/or homologous recombination. Binds RAD51 ａnd potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA （ssDNA）. Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A （RPA） from ssDNA ａnd stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, ａnd to ssDNA in tailed duplexes ａnd replication fork structures.Subunit : Monomer ａnd dimer.Subcellular Location : nuclear protein.Tissue Specificity : Highest levels of expression in breast ａnd thymus, with slightly lower levels in lung, ovary ａnd spleen.DISEASE : Defects in BRCA2 are a cause of susceptibility to breast cancer （BC）. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically ａnd genetically heterogeneous. Important genetic factors have been indicated by familial occurrence ａnd bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.Defects in BRCA2 are the cause of pancreatic cancer type 2 （PNCA2） [MIM:613347]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine ａnd endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, ａnd lymphatic tissue.Similarity : Contains 8 BRCA2 repeats.BRCA2蛋白与DNA修复和重组有关， 乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关。 BRCA2是新近发现的一个抑癌基因，它在流行病学上与早期发现的BRCA1有许多相似之处。有学者发现：BRCA2在其它BRCA2突变的家族中也发现多发有结肠癌、肺癌、输尿管癌、脑瘤、胰腺癌和白血病等。BRCA2突变家族中这种肿瘤的多样性在其它研究中也有报道。