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Anti-BEGAIN/SAPAP大脑富含鸟苷酸激酶相关蛋白抗体
点击次数：246发布时间：2012/12/26 6:23:27
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-11335R
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货号：BY-11335R
英文名称：Anti-BEGAIN/SAPAP
中文名称：大脑富含鸟苷酸激酶相关蛋白抗体
其他名称：BEGAIN;BEGIN;Brain enriched guanylate kinase associated protein;Brain-enriched guanylate kinase-associated homolog （rat）;KIAA1446;SAP90/PSD95 Associated Proteins;SAPAP.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 65kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：BEGAIN is a 593 amino acid protein that localizes to cytoplasm ａnd membrane. BEGAIN interacts with PSD-95 ａnd SAPAP1 ａnd forms a ternary complex ａnd may sustain the structure of the postsynaptic density （PSD）. BEGAIN is a novel PSD component associated with the core complex of PSD-95 ａnd SAPAP. Because BEGAIN ａnd SAPAP interact with the same region of PSD-95, BEGAIN ａnd SAPAP may compete for the binding to PSD-95 ａnd cannot interact with PSD-95 simultaneously. The C-terminal region of BEGAIN is involved in the interaction with PSD-95 whereas the N-terminal region has a coiled-coil structure that may interact with other molecules. BEGAIN is specifically expressed in brain ａnd enriched in the PSD fraction. BEGAIN is also expressed in neurons ａnd enriched at synaptic junctions, ａnd is likely involved in the organization of synaptic junction components.Function : Brain-enriched guanylate kinase-associated protein （BEGAIN） interacts with postsynaptic density （PSD）-95/synapse-associated protein （SAP） 90. BEGAIN has been detected in nuclei ａnd at synapses in neurons.Subcellular Location : Cell Membrane, Cytoplasmic ａnd Plasma membrane
