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Anti-BRN3B/POU4F2脑特定蛋白Brn3B抗体
点击次数：262发布时间：2012/12/26 6:25:15
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-6985R
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货号：BY-6985R
英文名称：Anti-BRN3B/POU4F2
中文名称：脑特定蛋白Brn3B抗体
其他名称：BRN3B;class 4;transcription factor 2;Brain specific homeobox/POU domain protein 3B;Brain-3B;Brain-specific homeobox/POU domain protein 3B;Brn-3B;BRN3.2;Brn3b POU domain transcription factor;PO4F2_HUMAN;POU class 4 homeobox 2;POU domain;POU domain class 4 transcription factor 2;POU domain protein;POU4F2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 41kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog
产品介绍：The Brn family of transcription factors are found in a highly restricted subset of neurons ａnd are critical to the early embryonic development of the central nervous system. Brn-1 ａnd Brn-2 are class III POU （Pit-Oct-Unc） domain proteins, whereas Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described ａnd are designated Brn-3a, Brn-3b ａnd Brn-3c. While Brn-3a ａnd Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor. Interestingly, Brn-3a has two functional transactivating domains, one at the amino-terminus ａnd one at the carboxy-terminus. Brn-2 is thought to be involved in smooth muscle cell development ａnd differentiation.Function : Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons.Subcellular Location : Nucleus speckle.Tissue Specificity : Brain. Seems to be specific to the retina.Similarity : Belongs to the POU transcription factor family. Class-4 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain.Database links : UniProtKB/Swiss-Prot: Q12837.2
