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Anti-BECN1/Beclin 1/ATG6Bcl-2同源结构域蛋白抗体
点击次数：525发布时间：2012/12/26 6:25:40
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1353R
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货号：BY-1353R
英文名称：Anti-BECN1/Beclin 1/ATG6
中文名称：Bcl-2同源结构域蛋白抗体
其他名称：Beclin 1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 50kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, cow, hrs, dog, pig
产品介绍：Beclin 1 is the first identified mammalian gene to mediate autophagy ａnd also has tumor suppressor ａnd antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, ａnd normal growth control, ａnd is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners ａnd maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian ａnd prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells ａnd neurons.Function : Plays a central role in autophagy （By similarity）. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.Subcellular Location : Golgi apparatus > trans-Golgi network membrane. Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites ａnd cell bodies of cerebellar Purkinje cells.Tissue Specificity : Ubiquitous.Similarity : Belongs to the beclin family.BECN1是一种分子质量为60KDa的蛋白质, 它能与细胞凋亡抑制剂Bcl-2相互作用, 减少中枢神经系统的凋亡，参与PI3K复合物的组成和自噬体的形成。主要表达在胞质。抑癌基因beclin 1通过自噬作用来调节细胞生长。
