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Anti-BMI-1/PCGF4组蛋白相关Bmi1抗体
点击次数：214发布时间：2012/12/26 6:26:44
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-2999R
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货号：BY-2999R
英文名称：Anti-BMI-1/PCGF4
中文名称：组蛋白相关Bmi1抗体
其他名称：B lymphoma Mo MLV insertion region; Bmi 1; MGC12685; Murine leukemia viral （bmi 1） oncogene homolog; Oncogene BMI 1; PCGF 4; PCGF4; Polycomb complex protein BMI 1; Polycomb complex protein BMI-1; Polycomb group ring finger 4;Polycomb group RING finger protein 4; RING finger protein 51; BMI1; RNF51; RAD18.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 37kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, cow, chk, dog
产品介绍：The Bmi1 oncogene induces telomerase activity ａnd immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.Polycomb group （PcG） genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells （HSCs）, a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, ａnd its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal ａnd identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.产品图片Antigen: bs-2999P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
