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Anti-Brefeldin A/GBF1蛋白转运抑制剂GBF1抗体
点击次数：221发布时间：2012/12/26 6:27:09
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-11266R
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货号：BY-11266R
英文名称：Anti-Brefeldin A/GBF1
中文名称：蛋白转运抑制剂GBF1抗体
其他名称：ARF1GEF;BFA resistant GEF 1;BFA-resistant GEF 1;FLJ21263;FLJ21500;GBF1;GBF1_HUMAN;Golgi specific brefeldin A resistance factor 1;Golgi specific Brefeldin A-resistance factor;Golgi-specific brefeldin A-resistance guanine nucleotide exchange;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1;KIAA0248;MGC134877;MGC134878.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 206kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Protein trafficking to the membrane requires formation of coated carrier vesicles, such as COPI-coated vesicles from the cis-golgi, a process triggered by membrane binding of the GTP-bound form of ADP-ribosylation factors. Normally, brefeldin A （BFA） blocks this action by inhibiting guanine nucleotide exchange factors （GEFs） for ADP-ribosylation factor. However, GBF1, a member of the sec7-domain family of GEFs, allows cells to maintain normal golgi morphology ａnd grow in the presence of BFA. The gene encoding the human GBF1 protein maps to chromosome 10q24, with the sec7-domain centrally positioned, ａnd a proline-rich C-terminus. Based on mutatagenesis analysis, this proline rich region appears to interact with p115 in a functionally significant manner.Function : Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP.Tissue Specificity : Ubiquitous.Similarity : Contains 1 SEC7 domain.
