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Anti-BIN2/BRAP1乳腺癌相关蛋白1抗体
点击次数：186发布时间：2012/12/26 6:34:44
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-9727R
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货号：BY-9727R
英文名称：Anti-BIN2/BRAP1
中文名称：乳腺癌相关蛋白1抗体
其他名称：BIN2;BIN2_HUMAN;BRAP 1;Breast cancer associated protein BRAP1;Breast cancer-associated protein 1;Bridging integrator 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 62kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：BAR proteins are characterized by a common N-terminal BAR （bin, amphiphysin ａnd Rvs161/167） domain ａnd are recognized as adaptor proteins that are involved in many cellular processes. BIN1 ａnd BIN2 are BAR proteins that share 61% sequence similarity. BIN1 （Bridging integrator 1） is a ubiquitously expressed regulatory protein for synaptic vesicle endocytosis. BIN1 also interacts with the transcription factors c-Myc ａnd MyoD, potentially functioning as a tumor suppressor. BIN2, also known as Breast cancer-associated protein 1, is a 565 amino acid protein that interacts with BIN1. In contrast to BIN1, BIN2 lacks tumor suppressor features as well as a c-Myc interacting region. BIN2 shows preferred expression in tissues of hematopoietic origin, with high levels found in spleen, thymus, colon, placenta, lymphoid ａnd granulocytic cells. There are two isoforms of BIN2 that are produced as a result of alternative splicing events.Subcellular Location : Cytoplasm.Tissue Specificity : Highest level expression seen in spleen ａnd peripheral blood leukocytes ａnd is also expressed at high levels in thymus, colon ａnd placenta, suggesting preferential expression in hematopoietic tissues.
