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Anti-phospho-BACE1(Ser498)磷酸化β分泌酶抗体
点击次数：294发布时间：2012/12/26 6:40:10
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5215R
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货号：BY-5215R
英文名称：Anti-phospho-BACE1（Ser498）
中文名称：磷酸化β分泌酶抗体
其他名称：APP beta secretase; Asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE; Beta secretase 1; Beta secretase; Beta site amyloid beta A4 precursor protein cleaving enzyme; Beta site amyloid precursor protein cleaving enzyme 1; Beta site amyloid precursor protein cleaving enzyme; Beta site APP cleaving enzyme 1; Beta site APP cleaving enzyme; FLJ90568; HSPC104; KIAA1149; Memapsin 2; Memapsin2; Membrane associated aspartic protease 2; Transmembrane aspartic proteinase Asp2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 51kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb, hrs, chk, dog, cow
产品介绍：Accumulation of the amyloid-b（Ab）plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer＇s disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor （APP） at b-and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein ａnd a membrane anchored 99-amino acid carboxy-terminal fragment （C99）. The C99 fragment serves as substrate for g-secretase to generate the 4kD amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought b-secretase was recently identified by several groups independently ａnd designated beta-site APP cleaving enzyme （BACE） ａnd aspartyl protease 2 （Asp2）. BACE/Asp2 is a novel transmembrane aspartic protease ａnd colocalizes with APP. This antibody can be used for detection of BACE by Western blot at 0.5 to 1 ug/ml. Human brain tissue lysate can be used as positive control ａnd an approximately 70kD band should be detected. It is human ａnd mouse reactive.
