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Anti-Phospho-Bad(Ser134)磷酸化相关死亡促进因子抗体
点击次数：213发布时间：2012/12/26 6:41:05
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5217R
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货号：BY-5217R
英文名称：Anti-Phospho-Bad（Ser134）
中文名称：磷酸化相关死亡促进因子抗体
其他名称：BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 18kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Bad is a member of the Bcl2 family ａnd acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 ａnd BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL ａnd the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.BAD是BCL2/BAX,BCL-XL/BAX异二聚体的负调节基因。BAD是BCL2/BCL-XL相关死亡促进因子，作为BCL2, bCL-XL异二聚体伴分子而促进细胞凋亡。
