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Anti-Phospho-Bcl-2(Thr129)磷酸化Bcl-2抗体
点击次数：222发布时间：2012/12/26 6:44:17
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5220R
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货号：BY-5220R
英文名称：Anti-Phospho-Bcl-2（Thr129）
中文名称：磷酸化Bcl-2抗体
其他名称：Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 26kDa
纯化方法：affinity purified by Protein A
交叉反应：rat, mo, hu, pig, cow, hrs, shp, dog
产品介绍：BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants （alpha ａnd beta） produced by alternate splicing, differ in their C-terminal ends. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic ａnd neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor （APAF1）. It can form homodimers, ａnd heterodimers with BAX, BAD, BAK ａnd BclX（L）. Heterodimerization with BAX requires intact BH1 ａnd BH2 domains, ａnd is necessary for anti-apoptotic activity.
