本公司经销Bag1/RAP46，抑凋亡基因bag1抗体，克隆类型为polyclonal，宿主来源是Rabbit，Bag1/RAP46抑凋亡基因bag1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3664R
英文名称：Anti-Bag1/RAP46
中文名称：抑凋亡基因bag1抗体
其他名称：Bag 1; Bag-1; BAG family molecular chaperone regulator 1; BCL 2 Associated Athanogene 1; BCL 2 associated athanogene; BCL 2 binding athanogene 1; BCL2 associated athanogene 1; BCL2 associated athanogene; Glucocorticoid receptor-associated protein RAP46; HAP1 antibody Haptoglobin; RAP 46; RAP46.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 39kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog
产品介绍：The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 ａnd is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 ａnd represents a link between growth factor receptors ａnd anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG （CUG） initiation codon, ａnd three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq].Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, ａnd has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.Function : Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, ａnd has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.Subunit : Contains 1 BAG domain.Contains 1 ubiquitin-like domain.Subcellular Location : Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast ａnd uterine myometrium. Isoform 1 is expressed in the ovary ａnd testis. Isoform 4 is expressed in several types of tumor cell lines, ａnd at consistently high levels in leukemia ａnd lymphoma cell lines. Isoform 1 is expressed in the prostate, breast ａnd leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines.Tissue Specificity : Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm ａnd shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus ａnd Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes （what appears to be the nuclear envelope ａnd perinuclear membranes） as well as punctate cytosolic structures suggestive of mitochondria.Bag1蛋白是一种多功能蛋白，起到抑凋亡的作用，与Bcl 2、Raf 1等联合，一同调节一些生长因子及其受体酪氨酸激酶，协同热休克蛋白70发挥转录调节的分子作用。