本公司经销Phospho-Bad（Ser136），磷酸化相关死亡促进因子抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-Bad（Ser136）磷酸化相关死亡促进因子抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3056R
英文名称：Anti-Phospho-Bad（Ser136）
中文名称：磷酸化相关死亡促进因子抗体
其他名称：BAD （Phospho-Ser136）; BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 18kDa
纯化方法：affinity purified by Protein A
交叉反应：mo
产品介绍：Bad is a member of the Bcl2 family ａnd acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 ａnd BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL ａnd the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.Subunit : Forms heterodimers with the anti-apoptotic proteins, Bcl-X（L）, Bcl-2 ａnd Bcl-W. Also binds protein S100A10 （By similarity）. The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins （By similarity）. Interacts with AKT1 ａnd PIM3.Subcellular Location : Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.Tissue Specificity : Expressed in a wide variety of tissues.Similarity : Belongs to the Bcl-2 family.BAD是BCL2/BAX、BCL-XL/BAX异二聚体的负调节基因。BAD是BCL2/BCL-XL相关死亡促进因子，作为BCL2、 bCL-XL异二聚体伴分子而促进细胞凋亡。有学者认为：BAD缺乏典型的羧基端跨膜结构，提示其并非一完整膜蛋白。与同BCL2作用相比，BAD与BCL-XL的结合更强，BAD以浓度依赖性方式替换BCL-XL/BAX、BCL2/BAX异二聚体中的BAX，使BAX游离而促进细胞凋亡。当一细胞系的所有细胞内异二聚体（BCL-XL/BAX和BCL2/BAX）的含量≥50%时，则细胞耐受凋亡；而当细胞内BAX同二聚体＞80%时且在适当信号诱导下则细胞出现凋亡。这表明BAD通过调节BAX同二聚体与异二聚体量的比值而介导凋亡。