本公司经销BAT3/BAG6，Bcl2相关抗凋亡基因6抗体，克隆类型为polyclonal，宿主来源是Rabbit，BAT3/BAG6Bcl2相关抗凋亡基因6抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7657R
英文名称：Anti-BAT3/BAG6
中文名称：Bcl2相关抗凋亡基因6抗体
其他名称：family molecular chaperone regulator 6;BAG-6;BAG6;Bag6;BAG6_HUMAN;BCL2-associated athanogene 6;D6S52E;G3; HLA B associated transcript 3;HLA-B-associated transcript 3;Large proline-rich protein BAG6;Protein G3;Protein Scythe.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 119kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored （TA） membrane proteins to the endoplasmic reticulum membrane ａnd regulation of chromatin. Acts in part by regulating stability of proteins ａnd their degradation by the proteasome. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability ａnd preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination ａnd subsequent proteasomal degradation of HSPA2. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored （TA） membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins ａnd transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane.Function : Serine-threonine kinase which transduces inflammatory ａnd cell-death signals （necroptosis） following death receptors ligation, activation of pathogen recognition receptors （PRRs）, ａnd DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD ａnd TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via ＇Lys-63＇-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway ａnd the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation ａnd cell death. RIPK1 ａnd RIPK3 association, in particular, forms a necroptosis-inducing complex.Subunit : Interacts （via RIP homotypic interaction motif） with RIPK3 （via RIP homotypic interaction motif）; this interaction induces RIPK1 necroptosis-specific phosphorylation, formation of the necroptosis-inducing complex. Interacts （via the death domain） with TNFRSF6 （via the death domain） ａnd TRADD （via the death domain）. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 ａnd TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK.Post-translational modifications : Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation ａnd enhances pro-apototic signaling through the TRADD-FADD interaction.RIPK1 ａnd RIPK3 undergo reciprocal auto- ａnd trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is necessary for the formation of the necroptosis-inducing complex.Ubiquitinated by ＇Lys-11＇-, ＇Lys-48＇-, ＇Lys-63＇- ａnd linear-linked type ubiquitin. Polyubiquitination with ＇Lys-63＇-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of ＇Lys-63＇-linked chains ａnd polyubiquitination with ＇Lys-48＇-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation ａnd consequently downregulates TNF-alpha-induced NFkappa-B signaling. Linear polyubiquitinated; the head-to-tail polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated with ＇Lys-11＇-linked chains.Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 death domain. Contains 1 protein kinase domain.