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Anti-Bestrophin 2卵黄状黄斑病蛋白2抗体
点击次数：281发布时间：2012/12/26 6:55:21
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-11041R
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货号：BY-11041R
英文名称：Anti-Bestrophin 2
中文名称：卵黄状黄斑病蛋白2抗体
其他名称：BEST 2;Best disease Bestrophin;BEST2;Bestrophin2;FLJ20132;Vitelliform macular dystrophy 2 homolog;Vitelliform macular dystrophy 2 like 1;Vitelliform macular dystrophy 2 like protein 1;Vitelliform macular dystrophy;VMD2;VMD2 like gene 1;VMD2L1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy （VMD）, 1 also known as Best disease. Three more members of the bestrophin family members were cloned ａnd indentified recently, Bestrophin 2, 3 ａnd 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 ａnd Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers ａnd pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A （PP2Ac）. Such protein protein interaction between Bestrophin ａnd PP2Ac ａnd the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac ａnd the Bestrophin takes place near the carboxy terminal end of the protein.Subcellular Location : Cell Membrane
