产品展示
Anti-BRD7鼻咽癌相关转录调节蛋白抗体
点击次数：320发布时间：2012/12/26 6:59:50
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-7779R
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货号：BY-7779R
英文名称：Anti-BRD7
中文名称：鼻咽癌相关转录调节蛋白抗体
其他名称：75 kDa bromodomain protein;BP75;BRD 7;BRD7;BRD7_HUMAN;Bromodomain containing 7;bromodomain containing protein 7;Bromodomain-containing protein 7;CELTIX 1;CELTIX1;NAG4;Protein CELTIX-1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 74kDa
纯化方法：affinity purified by Protein A
交叉反应：human, chicken, cow, dog, zebrafish, rhesus monkey, Orangutan
产品介绍：Acts both as coactivator ａnd as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at ＇Tyr-216＇. Down-regulates TRIM24-mediated activation of transcriptional activation by AR （By similarity）. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at ＇Lys-9＇ （H3K9ac）. Binds to the ESR1 promoter. Recruits BRCA1 ａnd POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at ＇Lys-382＇, ａnd thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.BRD7可能参与了基因转录调控,是一个核转录调节蛋白。经研究发现BRD7可能是通过Ras/MEK/ERK和Rb/E2F两条通路影响细胞周期的进程，使细胞停滞于G0/G1期，BRD7具有阻止细胞周期进程的作用。BRD7蛋白尤其是在鼻咽癌的发病过程中发挥了十分重要作用，BRD7基因的过表达可通过调节MAPK及Wnt信号通路抑制鼻咽癌的生长，并将鼻咽癌阻滞在G1/S期。
