本公司经销BPTF/FALZ，胎儿阿兹海默病抗原/核小体重塑因子抗体，克隆类型为polyclonal，宿主来源是Rabbit，BPTF/FALZ胎儿阿兹海默病抗原/核小体重塑因子抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11641R
英文名称：Anti-BPTF/FALZ
中文名称：胎儿阿兹海默病抗原/核小体重塑因子抗体
其他名称：Bromodomain ａnd PHD finger containing transcription factor;Bromodomain PHD finger transcription factor;FAC 1;BPTF / FALZ;fac1;FALZ;Fetal Alz 50 clone 1 protein;Fetal Alz 50 reactive clone 1;Fetal Alzheimer antigen;Nucleosome remodeling factor;Nucleosome remodeling factor subunit BPTF;Nucleosome remodeling factor, large subunit;NURF 301;NURF301.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 324kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：BPTF is a 2,907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family ａnd contains one bromodomain, one DDT domain ａnd two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF （nucleosome-remodeling factor）. The NURF complex, which consists of SMARCA1, BPTF, RbAp46 ａnd RbAp48, acts to catalyze ATP-dependent nucleosome sliding ａnd facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on ＇Lys-4＇ （H3-K4Me3）, which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.Function : BPTF is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF （nucleosome remodelling factor）. NURF catalyses ATP-dependent nucleosome sliding ａnd facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain ａnd spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer＇s disease.Subcellular Location : Cytoplasmic ａnd Nuclear