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Anti-BBC3/PUMAp53正向细胞凋亡调控因子抗体
点击次数：298发布时间：2012/12/26 7:03:23
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1573R
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货号：BY-1573R
英文名称：Anti-BBC3/PUMA
中文名称：p53正向细胞凋亡调控因子抗体
其他名称：bcl-2 binding component 3; BBC 3; BBC3; BCL 2 binding component 3; BCL2 binding component 3; JFY 1; JFY1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 21kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, pig
产品介绍：PUMA is an essential mediator of p53-dependent ａnd p53-independent apoptosis. It is localized in the mitochondria ａnd induces cytochrome c release ａnd activates the rapid induction of programmed cell death. There are two isoforms, alpha ａnd beta. Apoptosis is related to many diseases ａnd development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently ａnd designated PUMA （for p53 upregulated modulator of apoptosis） ａnd bbc3 （for Bcl-2 binding component 3） in human ａnd mouse （1-3）. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax ａnd Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a ａnd PUMA-b （1）. PUMA proteins bind Bcl-2, localize to the mitochondria, ａnd induce cytochrome c release ａnd apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.Function : Essential mediator of p53-dependent ａnd p53-independent apoptosis.Subunit : Belongs to the Bcl-2 family.Subcellular Location : Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.Tissue Specificity : Ubiquitously expressed.PUMA在由p53诱导而经历细胞凋亡的细胞中被p53活化。在线粒体，PUMA 诱导细胞色素C的释放和激活对细胞凋亡的快速诱导。PUMA 与Bcl2、Bcl-XL、类Bcl2-1蛋白相互作用，促使线粒体易位和BAX的多聚化。PUMA在通过依赖细胞色素C/APAF1 途径介导p53诱导的细胞死亡中也发挥作用。
