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Anti-Phospho-CRMP2 (Thr514+Ser518)磷酸化二氢嘧啶酶样2抗体
点击次数：307发布时间：2012/12/26 7:24:56
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-8284R
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货号：BY-8284R
英文名称：Anti-Phospho-CRMP2 （Thr514+Ser518）
中文名称：磷酸化二氢嘧啶酶样2抗体
其他名称：CRMP2 （phospho T514 + S518）;CRMP2 （phospho T514+S518）;CRMP-2（phospho Thr514+S518）;p-CRMP2（Thr514+S518）;CRMP2/Dpysl2（DRP 2; Collapsin response mediator protein 2; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; DHPRP 2; DHPRP2; Dihydr pyrimidinase 2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form;Dihydropyrimidinase related protein 2; DPYL 2; DPYL2; DPYSL 2; DPYSL2; DRP 2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; Ulip2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 62kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Collapsin response mediator proteins （CRMPs） are cytosolic phosphoproteins involved in neuronal differentiation ａnd axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons ａnd to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics ａnd axon induction. CRMPs localize to the lamellipodia ａnd filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, ａnd appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly ａnd modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 （PLD2）, the cytosolic tyrosine kinase Fes, ａnd intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer＇s disease.CRMP2是一种脑特异性蛋白，对于轴突生长和轴突-树突发育起到很重要的作用，CRMP2通过与微管蛋白二聚体结合并促进微管的组装来调控轴突的生长和分支。
