本公司经销CK19/CK17/CK14/CK10/CK42，细胞角蛋白19，17，14，42，10抗体，克隆类型为polyclonal，宿主来源是Rabbit，CK19/CK17/CK14/CK10/CK42细胞角蛋白19，17，14，42，10抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11185R
英文名称：Anti-CK19/CK17/CK14/CK10/CK42
中文名称：细胞角蛋白19，17，14，42，10抗体
其他名称：CK-19; CK 19; 40 kDa keratin intermediate filament; CK 19; Cytokeratin19; ck19; Cytokeratin 19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366;Cytokeratin 17;Cytokeratin 19;Cytokeratin 14;Cytokeratin 42;Cytokeratin 10;CK 19; CK 17; CK 14; CK 42; CK10.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 44kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, cow, chk, pig, dog
产品介绍：The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells ａnd are subdivided into cytokeratins ａnd hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.Function : Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.Subunit : Heterotetramer of two type I ａnd two type II keratins. Interacts with PNN ａnd the actin-binding domain of DMD. Interacts with HCV core protein.DISEASE : Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland ａnd mammary gland ductal ａnd secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium （at protein level）. Expressed in epidermal basal cells, in nipple epidermis ａnd a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins ａnd artery of human umbilical cord, ａnd in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin ａnd spectrin.