本公司经销CK10/Cytokeratin 10，细胞角蛋白10抗体，克隆类型为polyclonal，宿主来源是Rabbit，CK10/Cytokeratin 10细胞角蛋白10抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11186R
英文名称：Anti-CK10/Cytokeratin 10
中文名称：细胞角蛋白10抗体
其他名称：type I cytoskeletal 10;BCIE;BIE;CK 10;CK-10;ck10;Cytokeratin 10;Cytokeratin-10;Cytokeratin10;EHK;k10;K1C10_HUMAN;Keratin 10;Keratin;Keratin type i cytoskeletal 10;Keratin type I cytoskeletal 59 kDa;Keratin-10;Keratin10;kpp;Krt 10;KRT10;krt10.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 55kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog
产品介绍：Cytokeratins comprise a diverse group of intermediate filament proteins （IFPs） that are expressed as pairs in both keratinized ａnd non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation ａnd tissue specialization ａnd function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 ａnd 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 10 is a heterotetramer of two type I ａnd two type II keratins, is generally associated with keratin 1, ａnd is seen in all suprabasal cell layers including stratum corneum.Subunit : Belongs to the intermediate filament family.Subcellular Location : Cytoplasm.Tissue Specificity : Seen in all suprabasal cell layers including stratum corneum.DISEASE : Defects in KRT10 are a cause of bullous congenital ichthyosiform erythroderma （BCIE） [MIM:113800]; also known as epidermolytic hyperkeratosis （EHK） or bullous erythroderma ichthyosiformis congenita of Brocq. BCIE is an autosomal dominant skin disorder characterized by widespread blistering ａnd an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma ａnd blister formation diminish ａnd hyperkeratoses develop.Defects in KRT10 are a cause of ichthyosis annular epidermolytic （AEI） [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood ａnd hyperkeratotic lichenified plaques in the flexural areas ａnd extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface ａnd can persist for several weeks or even months.