本公司经销Cytokeratin 5/CK5，细胞角蛋白5抗体，克隆类型为polyclonal，宿主来源是Rabbit，Cytokeratin 5/CK5细胞角蛋白5抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1440R
英文名称：Anti-Cytokeratin 5/CK5
中文名称：细胞角蛋白5抗体
其他名称：Cytokeratin 5; Keratin, type II cytoskeletal 5; CK-5; Keratin-5; K5; 58 kDa cytokeratin; KRT5; CK 5; DDD; EBS 2; EBS2; K5; Keratin 5 （epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types）; Keratin 5; Keratin Type II Cytoskeletal 5; Keratin5; KRT 5; KRT 5A; KRT5.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 64kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, cow, hrs, Rb
产品介绍：Cytokeratins （CK） are intermediate filaments of epithelial cells, both in keratinising tissue （ie., skin） ａnd non keratinising cells （ie., mesothelial cells）. Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins （CK） in the molecular range of 40 to 70 kDa ａnd isoelectric points of 5 to 8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I （acidic polypeptides） ａnd type II （basic polypeptides）. At least one member of the acidic family ａnd one member of the basic family is expressed in all epithelial cells. Defects in KRT5 are a cause of epidermolysis bullosa simplex.Subunit : Belongs to the intermediate filament family.DISEASE : Defects in KRT5 are a cause of epidermolysis bullosa simplex Dowling-Meara type （DM-EBS） [MIM:131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, ａnd mucous membrane involvement.Defects in KRT5 are the cause of epidermolysis bullosa simplex with migratory circinate erythema （EBSMCE） [MIM:609352]. EBSMCE is a form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, ａnd legs but spare nails, ocular epithelia ａnd mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.细胞角蛋白5，为高分子量细胞角蛋白 58 kDa ，表达在皮肤的基底细胞和棘层细胞，部分前列腺基底细胞，与其它单层腺上皮不表达。主要用于间皮瘤与腺癌的鉴别诊断。细胞角蛋白是一类与结构相关的蛋白家族，其在上皮细胞中形成细胞骨架中间丝。CK5是在表皮角质化细胞中大量表达的4种角蛋白。CK5可用以区分正常细胞和肿瘤细胞。在基底细胞上皮瘤、多种鳞状细胞癌（皮肤和舌）、多种上皮细胞和间皮瘤都有CK5的表达。