"本公司经销CNG channel beta 1/truncated GARP，环核苷酸门控阳离子通道蛋白CNG-1β抗体，克隆类型为polyclonal，宿主来源是Rabbit，CNG channel beta 1/truncated GARP环核苷酸门控阳离子通道蛋白CNG-1β抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11332R
英文名称：Anti-CNG channel beta 1/truncated GARP
中文名称：环核苷酸门控阳离子通道蛋白CNG-1β抗体
其他名称：CNCG 4;CNCG2;CNCG3L;CNCG4;CNG 4;CNG channel 4;CNG channel beta 1;CNG4;CNGB 1;CNGB1;CNGB1B;Cyclic nucleotide gated cation channel 4;Cyclic nucleotide gated cation channel;Cyclic nucleotide gated cation channel beta 1;Cyclic nucleotide gated cation channel gamma;Cyclic nucleotide gated cation channel modulatory subunit;Cyclic nucleotide gated channel （photoreceptor） cGMP gated 3 （gamma） like;Cyclic nucleotide gated channel beta 1;GAR1;GARP;GARP2;Glutamic acid rich protein;RCNC2;RCNCb;RCNCbeta;RP45;240 kDa protein of rod photoreceptor CNG channel;cGMP gated cation channel beta subunit;Truncated glutamic acid rich protein;Truncated rod photoreceptor cGMP gated channel beta subunit;Truncated rod photoreceptor cGMP-gated channel beta-subunit.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Glutamic acid rich protein （GARP） is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated （CNG） channels, nonselective cation channels, which play important roles in both visual ａnd olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment （ROS）, in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase （PDE6）-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor ＇dark noise＇ ａnd allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 （RP25）. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness ａnd loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field ａnd eventually central vision as well. Subcellular Location : Membrane; Multi-pass membrane protein."