本公司经销CPLX2，突触融合蛋白2抗体，克隆类型为polyclonal，宿主来源是Rabbit，CPLX2突触融合蛋白2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11342R
英文名称：Anti-CPLX2
中文名称：突触融合蛋白2抗体
其他名称：Complexin 2;Complexin II;Complexin-2;Complexin2;ComplexinII;CPLX 2;Cplx2;CPLX2_HUMAN;CPX 2;CPX II;CPXII;Hfb1;Synaphin 1;Synaphin-1;Synaphin1;921 L.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 15kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Complexin 1 ａnd Complexin 2, also designated Synaphin 1 ａnd Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 ａnd Complexin 2 are expressed in presynaptic terminals of inhibitory ａnd excitatory hippocampal neurons, respectively, ａnd in cytoplasmic pools during early stages of development. Complexins promote SNARE （soluble N-ethylmaleimide-sensitive factor attachment protein receptors） precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release ａnd preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP （long term potentiation） following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional ａnd cognitive dysfunctions seen in these mice.Function : Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis.Subcellular Location : Cytoplasm > cytosol. Enriched at synaptic-releasing sites in mature neurons.Tissue Specificity : Nervous system. In hippocampus ａnd cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.Similarity : Belongs to the complexin/synaphin family.