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Anti-Cystatin A胱抑素A/半胱氨酸蛋白酶抑制剂A抗体
点击次数：321发布时间：2012/12/26 8:14:33
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-4937R
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货号：BY-4937R
英文名称：Anti-Cystatin A
中文名称：胱抑素A/半胱氨酸蛋白酶抑制剂A抗体
其他名称：CSTA; CSTA protein; Cystatin A; Cystatin AS; Cystatin-A; Cystatin-AS; CystatinA; CYTA_HUMAN; Stefin A; Stefin A1; Stefin-A; StefinA; STF 1; STF1; STFA.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 11kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, Rb
产品介绍：Cystatin A ａnd cystatin B （also designated PME, CST6, STFB, CPI-B, stefin B ａnd liver thiol proteinase inhibitor） are thiol protease inhibitors that form complexes with papain ａnd the cathepsins B, H, ａnd L. Cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes ａnd plays a role in epidermal development ａnd maintenance. Cystatin B protects against intracellular proteases leaking out of lysosomes ａnd is primarily expressed in heart, liver ａnd kidney.Function : This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed in the skin throughout the epidermis.DISEASE : Defects in CSTA are the cause of ichthyosis exfoliative autosomal recessive ichthyosis bullosa of Siemens-like （AREI） [MIM:607936]. A form of congenital exfoliative ichthyosis, sharing some features with ichthyosis bullosa of Siemens ａnd annular epidermolytic ichthyosis. AREI presents shortly after birth as dry, scaly skin over most of the body with coarse peeling of non-erythematous skin on the palms ａnd soles, which is exacerbated by excessive moisture ａnd minor trauma. Electron microscopy analysis of skin biopsies, reveals mostly normal-appearing upper layers of the epidermis, but prominent intercellular edema of the basal ａnd suprabasal cell layers with aggregates of tonofilaments in the basal keratinocytes.Similarity : Belongs to the cystatin family.
