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货号：BY-11078R
英文名称：Anti-Cadherin 8
中文名称：钙粘附蛋白8抗体
其他名称：CADH8_HUMAN;Cadherin 8, type 2;Cadherin-8;CDH 8;CDH8;Putative protein product of Nbla04261.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 88kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure ａnd morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including catenin b, to regulate cadherin function. Cadherin-8 expression has been seen in mouse thymus tissue as well as in specific subdivisions of the developing central nervous system. It plays a potential role in brain morphology.Function : Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.Subunit : Contains 5 cadherin domains.Subcellular Location : Cell membrane.Tissue Specificity : Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells ａnd neuroblasts.
