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Anti-CRTAMT细胞调控相关蛋白抗体
点击次数：262发布时间：2012/12/26 8:26:45
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-4957R
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货号：BY-4957R
英文名称：Anti-CRTAM
中文名称：T细胞调控相关蛋白抗体
其他名称：Cytotoxic ａnd regulatory T-cell molecule; Class I MHC restricted T cell associated molecule.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 41kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb, pig
产品介绍：CRTAM, （class-I MHC-restricted T-cell associated molecule）, is an immunoglobulin-superfamily transmembrane protein ａnd a new member of the nectin-like （Necls） family. In the immune system, CRTAM expression has been shown to be restricted to activated class-I MHC-restricted T cells, including NKT ａnd CD8 T cells. CRTAM interacts with CADM1 ａnd promotes natural killer （NK） cell cytotoxicity ａnd interferon-gamma （IFN-gamma） secretion by CD8+ cells in vitro, as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Nectin-like （Necl） molecule 2, has been identified as a ligand of CRTAM. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within ａnd outside of the immune system.Subunit : Interacts with CADM1.Subcellular Location : Membrane; Single-pass type I membrane protein （Potential）.Tissue Specificity : In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT ａnd CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, ａnd in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung ａnd lymphoid tissues.Similarity : Belongs to the nectin family.CRTAM蛋白与调节细胞极性有关。细胞极性（cell polarity）的调控对于控制细胞的形态发生非常关键，并且这一过程在很多生物学功能中发挥着重要的作用，包括细胞分裂、分化、迁移等基础过程以及器官发生中的复杂行为等。细胞蛋白的空间结构排列是细胞极性形成的基础。抗原呈递细胞（antigen-presenting cell，APC）诱导T细胞的激活，而这会导致免疫突触（immunological synapse，IS）的形成、T细胞受体（TCR）接触信号衔接平台的组装、细胞支架的重组以及第二信使的产生等。
