产品展示
Anti-CLNS1A/pICln氯离子通道调节蛋白1A抗体
点击次数：223发布时间：2012/12/26 8:27:11
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-9851R
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详细内容
货号：BY-9851R
英文名称：Anti-CLNS1A/pICln
中文名称：氯离子通道调节蛋白1A抗体
其他名称：nucleotide sensitive 1A;Chloride channel;Chloride channel nucleotide sensitive 1A;Chloride channel regulatory protein;Chloride conductance regulatory protein ICln;Chloride ion current inducer protein;ClCI;CLNS 1A;Clns1a;CLNS1B;I（Cln）;ICln;ICLN_HUMAN;Methylosome subunit pICln;Reticulocyte pICln.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 26kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron （SMN） protein, ａnd is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines （sDMAs）. sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 （also designated Jak-binding protein 1, JBP1）, pICln, ａnd two novel factors. PRMT5 binds the Sm proteins via their arginine- ａnd glycine-rich （RG） domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, ａnd may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.Subcellular Location : Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. A small fraction is also associated with the cytoskeleton.
