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Anti-CSTF2T/CstF-64细胞分裂相关蛋白CSTF64抗体
点击次数：273发布时间：2012/12/26 8:29:56
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-6995R
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货号：BY-6995R
英文名称：Anti-CSTF2T/CstF-64
中文名称：细胞分裂相关蛋白CSTF64抗体
其他名称：CF1 64 kDa subunit, tau variant;Cleavage stimulation factor 64 kDa subunit, tau variant;CSTF 64 kDa subunit, tau variant;KIAA0689;TauCstF64.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 64kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF （cleavage stimulation factor）, a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain ａnd is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells ａnd in pre- ａnd postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic ａnd postmeiotic cells in the testis ａnd to a lesser extent in the brain, ａnd promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 （designated CSTF2） maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.Subcellular Location : Nuclear
