产品展示
Anti-CREB-H/CREB3L3环腺苷酸应答元件结合蛋白H抗体
点击次数：228发布时间：2012/12/26 8:34:39
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-11239R
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详细内容
货号：BY-11239R
英文名称：Anti-CREB-H/CREB3L3
中文名称：环腺苷酸应答元件结合蛋白H抗体
其他名称：cAMP responsive element binding protein 3 like 3;cAMP responsive element-binding protein 3 like protein 3;CREB H;CREB/ATF family transcription factor;CREBH;Cyclic AMP responsive element binding protein 3 like protein 3;cAMP-responsive element-binding protein 3-like protein 3;HYST1481;MGC126553;MGC126557;Transcription factor CREB H.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 49kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum （ER） and, in response to ER stress, is cleaved ａnd translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response ａnd the acute phase response （APR）. Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer ａnd contains one leucine zipper domain, a KDEL-like sequence ａnd a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.Subcellular Location : Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus.
