本公司经销CK7，细胞角蛋白7抗体，克隆类型为polyclonal，宿主来源是Rabbit，CK7细胞角蛋白7抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1744R
英文名称：Anti-CK7
中文名称：细胞角蛋白7抗体
其他名称：Cytokeratin 7; CK 7; K7; Keratin 7; Keratin,type II cytoskeletal 7; KRT7; SCL.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 54kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat
产品介绍：Cytokeratins are a subfamily of intermediate filament proteins ａnd are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa ａnd 68 kDa ａnd isoelectric pH between 4.9 – 7.8. The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology ａnd flow cytometric assays.Function : Blocks interferon-dependent interphase ａnd stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA （HPV16 E7）.Subunit : Heterotetramer of two type I ａnd two type II keratins. Interacts with eukaryotic translation initiator factor 3 （eIF3） subunit EIF3S10 ａnd with HPV16 E7.Subcellular Location : Cytoplasm.Tissue Specificity : Expressed in cultured epidermal, bronchial ａnd mesothelial cells but absent in colon, ectocervix ａnd liver. Observed throughout the glandular cells in the junction between stomach ａnd esophagus but is absent in the esophagus.Post-translational modifications : Arg-20 is dimethylated, probably to asymmetric dimethylarginine.Similarity : Belongs to the intermediate filament family.结构蛋白（Structural Proteins） CK-7是一种 54KDa 的中间丝蛋白，存在于大多数正常组织的腺上皮和移行上皮细胞中。 该抗体与多种良/恶性上皮性肿瘤反应。腺癌中的卵巢、乳腺、肺的腺癌呈阳性反应，而胃肠道的腺癌阴性。移行细胞肿瘤、前列腺癌也呈阳性反应。通常认为 CK7是腺癌和移行上皮细胞癌的比较特异性的标志。