产品展示
Anti-phospho-CREB-1(Ser133)磷酸化CREB-1抗体
点击次数：245发布时间：2012/12/26 8:38:53
更新日期：2024/9/5 14:43:40
所 在 地：其它
产品型号：BY-0036R
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详细内容
货号：BY-0036R
英文名称：Anti-phospho-CREB-1（Ser133）
中文名称：磷酸化CREB-1抗体
其他名称：CREB（Phospho-Ser133）; Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 43kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, pig, dog, chk, cow, shp
产品介绍：The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element （CRE） palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization ａnd basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family ａnd with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP （CREB-binding protein）, which may reprecent a CREB co-activator.磷酸化环腺苷酸应答元件结合蛋白（p-cAMP responsive element binding protein-1, p-CREB-1）是真核细胞转录因子，属于ATF/CREB家族。参与由cAMP或某些病毒蛋白质所诱导基因转录的调节。
